Cardinals vs. 49ers odds, spread, streak: Monday Night Football Mexico City picks, best NFL model predictions

Estadio Azteca will host its fourth-ever NFL game in Mexico on Monday Night Football. The Arizona Cardinals and San Francisco 49ers will face off in a rematch for their first NFL game outside the United States, as the Cardinals beat the 49ers in Mexico City in 2005. Arizona won both games against San Francisco during the 2021 season, but the Cardinals are only 4-6 To start the 2022 campaign. The 49ers are 5-4 overall after two straight wins. Cardinals quarterback Kyler Murray is inactive due to a hamstring injury.

Kick-off is set for 8:15 PM ET. San Francisco is favored 10 points in the latest Cardinals vs. 49ers odds from Caesars Sportsbook, and the Over/Under for total points scored is 43. Before you lock up any 49ers vs. Cardinals draft picks or NFL Week 11 bets, you have to check out the NFL Predictions from SportsLine demo form.

The model, which simulates every NFL game 10,000 times, has run way over $7,000 for $100 players in top-rated NFL picks since its inception. The Model enters Week 7 of the 2022 NFL season with an incredible 153-108 run on the NFL’s highest-ranked draft picks going back to the 2017 season.

Model has also been ranked in the NFLPickWatch’s top 10 four of the past six years in NFL live picks and has beaten over 94% of CBS Sports Football Pick’em players four times during that time. Anyone who follows her is the way.

Now, the form is broken down into the 49ers vs. Cardinals game Monday night. You can head over to SportsLine to see the selections. Here are some betting lines and directions for the Cardinals vs. 49ers:

  • Cardinals vs. 49ers spread: San Francisco -10
  • Cardinals vs. 49ers over/under: 43 points
  • Cardinals money line vs. 49ers: San Francisco -480, Arizona +360
  • SF: Niners are 48-47-1 ATS (50.5%) under head coach Kyle Shanahan (since 2017)
  • AZ: The Cardinals are 31-27-2 ATS (53.4%) under head coach Cliff Kingsbury (since 2019).

Why the 49ers can cover

The 49ers are 3-0 against the spread in divisional play this season and have the best defense in the NFL in terms of total yardage. She allows 281 yards per game and scores 18 points per contest (4th). They also get after quarterbacks, posting 29 sacks, fifth most in the NFL. Nick Bosa is tied for second with 9.5 and leads the NFL with 24 quarterback hits. Arizona quarterbacks have been taken down 27 times, so the pressure will be on all night.

Arizona’s offense is 13th in scoring (23 points) and 19th in yards (334), while they score nearly 358 yards (23) and 26 points (30). Running back Christian McCaffrey has 226 total yards and three TDs in the previous two games, and quarterback Jimmy Garoppolo has plenty of elite options in the passing game. Deebo Samuel (576 total yards), Brandon Aiyuk (567 receiving) and George Kittle (29 passes) should find layers in a Cardinals defense that allows 247 passing yards per game (23rd overall). See which team to choose here.

Why can the Cardinals cover?

Arizona has quarterback uncertainty with Kyler Murray inactive with a hamstring injury. However, the Cardinals have a star wide receiver who makes life easier for backup Colt McCoy. DeAndre Hopkins is a five-time professional quarterback and three-time All-Pro and ranks in the top three among active players in career receptions, receiving yards, and receiving touchdowns. Hopkins averages nine catches a game this season and has 396 receiving yards since debuting in Week 7, the third-most for a player during that span.

Arizona scores 23.0 points per game, an above-average mark, and the Cardinals have had better-than-average first downs (206) and red zone efficiency (60.0%). The Cardinals are also in the top five in turnover avoidance, giving up just nine tackles, and San Francisco has only recorded 10 turnovers on defense in nine games. See which team to choose here.

How to make cardinals picks vs 49ers

The model detailed Monday night’s Cardinals vs. 49ers game from all angles. It tends to be less than the total, as the model indicates that shifts can impede offenses. The model also has a strong advantage against spread picking, saying one side takes up more than 50 percent of the time. You only get picks at SportsLine.

So who’s going to win the 49ers against the Cardinals on Monday Night Football in Mexico City? And which aspect of diffusion is more than 50 percent of the simulations accounted for? Visit SportsLine now to find out which 49ers side versus the Cardinals spread you should be all over, all from the model on a 153-108 roll in the NFL’s top-ranked picks.

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